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The Pharmacy profession has experienced
significant development over the past 55 years(1)
and has gradually changed From Product-focused to patient focused profession(2, 3).
With the progression of health services, life
expectancy has gradually increased in communities and their lifespan has been
more than ever before. This has led the population to become older and
comorbidity more than before(4, 5). Chronic diseases are common in
the elderly(6) and many of these are on
polypharmacy. Polypharmacy is often referred to
as “multi-drug treatment”. Polypharmacy has several definitions. One
of the most commonly used definitions, divided polypharmacy into two types:
minors (taking 2 medication) and major (taking more than 4 medication)(7,
8). In a study conducted in 2003 in
the United States, the incidence of polypharmacy in the elderly was about 7%,
and although people over 65 were less than 15% of the US population, about one
third of the medication was consumed by their(9). The
incidence of adverse drug reactions and drug interactions increases with
“polypharmacy”, with the risk of drug-related side effects with two
medication being about 13%, while in the case of treatment with 5 medications,
the risk is up to 58%; this risk will reach about 82% by seven medications(10). Polypharmacy usually occurs in
people with chronic illnesses such as diabetes, hypertension, hyperlipidemia
and more angina pectoris(6).

When the drug is prescribed for the disease, the
ultimate goal of prescribing is to achieve an optimal therapeutic outcome; The
optimal therapeutic outcome is the absence of drug related problems during the
course of treatment(1). A DRP is an undesirable patient
experience that involves drug therapy and that actually or potentially
interferes with a desired patient outcome(11). Although some of these
problems, such as idiosyncratic reactions, are inevitable, most of them can be
prevented. In a systematic review study conducted in 2007, the prevalence of
drug-related problems was 9.9 per 1000, 21% of which were preventable(12). Annually more than 1.5 million
preventable drug related problems occur in the United States, accounting for an
excess of $177 billion in terms of medication-related morbidity and mortality(13). Drug related problems can lead
to hospitalization, increased hospital stay, increased hospitalization costs,
and increased mortality in patients (14-16). Some specific situation make a person more prone
to drug related problems, some of these risk factors include:

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